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What is not known is whether the application of xanthohumol could influence the palmitoylation status of proteins.In this study, young and old mice were fed a diet supplemented with xanthohumol for 8 weeks.

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The higher level of protein palmitoylation was also associated with poorer learning scores.

Xanthohumol is a prenylated flavonoid that has been shown to increase beta-oxidation in the livers of rodents, decreasing circulating free fatty acids in the serum.

Xanthohumol treatment was unable to affect the palmitoylation of NMDA receptor subunits and associated proteins assessed in this study.

This evidence suggests that xanthohumol may play a role in improving cognitive flexability in young animals, but it appears to be ineffective in adjusting the palmitoylation status of neuronal proteins in aged individuals.

Spatial memory was assessed with the Morris water maze and protein palmitoylation quantified.

The young xanthohumol-treated mice showed a significant improvement in cognitive flexibility.

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